Cisplatin nephropathy: is cytotoxicity avoidable?
نویسندگان
چکیده
منابع مشابه
Cisplatin cytotoxicity is dependent on mitochondrial respiration in Saccharomyces cerevisiae
Objective(s): To understand the role of mitochondrial respiration in cisplatin sensitivity, we have employed wild-type and mitochondrial DNA depleted Rho0 yeast cells. Materials and Methods: Wild type and Rho0 yeast cultured in fermentable and non-fermentable sugar containing media, were studied for their sensitivity against cisplatin by monitoring growth curves, oxygen consumption, pH changes ...
متن کاملcisplatin cytotoxicity is dependent on mitochondrial respiration in saccharomyces cerevisiae
objective(s): to understand the role of mitochondrial respiration in cisplatin sensitivity, we have employed wild-type and mitochondrial dna depleted rho0 yeast cells. materials and methods: wild type and rho0 yeast cultured in fermentable and non-fermentable sugar containing media, were studied for their sensitivity against cisplatin by monitoring growth curves, oxygen consumption, ph changes ...
متن کاملCisplatin cytotoxicity is dependent on mitochondrial respiration in Saccharomyces cerevisiae
OBJECTIVES To understand the role of mitochondrial respiration in cisplatin sensitivity, we have employed wild-type and mitochondrial DNA depleted Rho0 yeast cells. MATERIALS AND METHODS Wild type and Rho0 yeast cultured in fermentable and non-fermentable sugar containing media, were studied for their sensitivity against cisplatin by monitoring growth curves, oxygen consumption, pH changes in...
متن کاملCytoplasmic initiation of cisplatin cytotoxicity.
The mechanism of action of cisplatin as a chemotherapeutic agent has been attributed to DNA binding, while its mechanism of action as a nephrotoxin is unresolved. Only approximately 1% of intracellular cisplatin interacts with DNA, primarily forming intrastrand cross-linked adducts, and many studies have implicated both nuclear and cytoplasmic causes of cisplatin-induced death in cultured cells...
متن کاملIs postoperative oliguria avoidable?
Postoperative salt and water retention has been recognized for most of this century. Does it matter? Can or should it be avoided? These are still questions about which debate continues. Pringle, in 1905, observed reduced urine volumes and weight gain in postoperative patients [31]. Wilkinson studied 27 patients perioperatively and observed a decrease in urinary concentrations of sodium and chlo...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2007
ISSN: 0931-0509,1460-2385
DOI: 10.1093/ndt/gfm378